Development of bioinformatics tools to predict protein structure parameters from nucleotide sequence data or other biological data. Application of bioinformatics techniques to gain understanding of fundamental biological processes. This includes:
1) Prediction of protein domain boundaries based on synonymous codon usage.
2) Prediction of protein-protein interaction mechanisms by analysing sequence alignment covariances.
3) Statistical quantification of the relationship between the resonance frequencies in nuclear magnetic resonance (NMR) and corresponding protein structure parameters.
In addition, the tools above will be combined with NMR experimental techniques to new methodologies and applied to biologically significant proteins. The methodologies may yield information about important processes such as protein-protein interactions, protein folding and ligand-binding to proteins.