Peng or Peng-Pilon in some publications
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Peer-Reviewed Articles
1. Dunstan, D. I., Bekkaoui, F., Pilon, M., Fowke, L. C., Abrams, S. R. (1988). Effects of absisic acid and analogues on the maturation of White Spruce (Picea Glauca) somatic embryos. Plant Science 58:77-84.
2. Bekkaoui, F., Pilon, M., Laine, E., Raju, D. S. S., Crosby, W. L. and Dunstan, D. I. (1988). Transient gene expression in electroporated Picea glauca protoplasts. Plant Cell Reports 7:481-484.
3. Tautorus, T. E., Bekkaoui, F., Pilon, M., Datla, R. S. S., Crosby, W. L., Fowke, L. C., Dunstan, D. I. (1989). Factors affecting transient gene expression in electroporated black spruce (Picea mariana) and jack pine (Pinus banksiana) protoplasts. Theor. Appl. Genet. 78:531-536.
4. Bekkaoui, F., Datla, R. S. S., Pilon, M., Tautorus, T. E., Crosby, W. L., Dunstan, D. I. (1990). The effects of promoter on transient expression in conifer cell lines. Theor. Appl. Genet. 79:353-359.
5. Pilon, M., Gullberg, M. and Lundgren, E. (1991). Transient expression of the CD2 cell surface antigen as a sortable marker to monitor high frequency transfection of human primary B cells. J. Immunology 146:1047-1051.
6. Peng, M. and Lundgren, E. (1992). Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellular activation and DNA synthesis. Oncogene 7: 1775-1782.
7. Peng, M. and Lundgren, E. (1993). Transient expression of the Epstein-Barr virus LMP1 gene in B-cell chronic lymphocytic leukemia cells, T cells, and hematopoietic cell lines: cell-type-independent induction of CD23, CD21 and ICAM-1. Leukemia 7:104-112.
8. Rowe, M., Peng-Pilon, M., Huen, D. S., Hardy, R., Croom-Carter, D., Lundgren, E. and Rickinson, A. B. (1994). The induction of BCL-2 by the Epstein-Barr virus LMP1 protein is a delayed response relative to surface marker and NF-kB activation. J. Virology 68:5602-5612.
9. Peng-Pilon, M., Ruuth, K., Lundgren, E. and Brodin, P. (1995). The cytoplasmic C-terminal domain but not the N-terminal domain of latent membrane protein 1 of Epstein-Barr virus is essential for B-cell activation. J. Gen. Virology 76:767-777.
10. Pilon, M. and Weisblat, D. A. (1997). A nanos homolog in leech. Development 124:1771-1780.
11. Pilon, M., Peng, X.-R., Spence, A. M., Plasterk, R. H. A. and Dosch, H.-M. (2000). The diabetes autoantigen ICA69 and its C. elegans homologue are conserved regulators of neuroendocrine secretion. Mol. Biol. Cell. 11:3277-3288.
12. Winer, S., Aststurov, I., Gaedigk, R., Hammond-McKibben, D., Pilon, M., Song, A., Kubiak, V., Karges, W., Arpaia, E., McKerlie, C., Zucker, P., Singh, B. and Dosch, H.-M. (2002). ICA69-null nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J. Immunol. 168:475-482.
13. Tune, C. E.,Pilon, M., Saiki, Y. and Dosch, H.-M. (2002). Sustained expression of the novel EBV-induced zinc finger gene, ZNFEB, is critical for the transition of B lymphocyte activation to oncogenic growth transformation. J. Immunol. 168:680-688.
14. Kang, D., Pilon, M. and Weisblat, D. A. (2002). Maternal and zygotic expression of a nanos-class gene in the leech Helobdella robusta: primordial germ cells arise from segmental mesoderm. Dev. Biol. 245: 28-41.
15. Mörck, C., Axäng, C. and Pilon, M. (2003). A genetic analysis of axon guidance in the C. elegans pharynx. Dev. Biol. 260:158-175.
16. Mörck, C., Rauthan, M., Wågberg, F. and Pilon, M. (2004). pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus. Dev. Biol. 272:403-418.
17. Tajsharghi, H., Pilon, M. and Oldfors, A. (2005). A Caenorhabditis elegans model of the myosin heavy chain IIa E706R mutation. Ann. Neurol. 58:442-448.
18. Mörck, C., Axäng, C., Goksör, M. and Pilon, M. (2006). Misexpresison of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Dev. Biol. 297:446-460.
19. Mörck, C. and Pilon, M. (2006). C. elegans feeding defective mutants have shorter body lengths and increased autophagy. BMC Dev. Biol. 6:39.
20. Axäng, C., Hall, D. H., and Pilon, M. (2007). The twisted pharynx phenotype in C. elegans. BMC Dev. Biol.7:61.
21. Molin, M., Pilon, M. and Blomberg, A. (2007). Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenoehabditis elegans. Proteomics 7:3764-3774.
22. Hellerer, T., Axäng, C., Brackmann, C., Hillertz, P., Pilon, M. and Enejder, A. (2007). Monitoring of lipid storage in C. elegans using CARS microscopy. P.N.A.S. 104:14658-14663.
23. Rauthan, M, Mörck, C. and Pilon, M. (2007). The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2. Dev. Biol. 311:185-199.
24. Cuc, N. T. T. and Pilon, M. (2007). Aphelenchoides besseyi as a parasite of Polianthes tuberosa in the Mekong Delta. J. Nematology 39:248-257.
25. Axäng, C., Rauthan, M., Hall, D. H. and Pilon, M. (2008). Developmental genetics of the C. elegans pharyngeal neurons NSML and NSMR. BMC Dev. Biol. 8:38.
26. Mörck, C., Olsen, L., Kurth, C., Persson, A., Storm, N. J., Svensson, E., Jansson, J.-O., Hellqvist, M., Enejder, A., Faergeman, N. and Pilon, M. (2009). Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode C. elegans. P.N.A.S. 106:18285-18290.
27. Nguyen Thi Thu Cuc, Nguyen Thanh Son, Tran Minh Trung, Nguyen văn Trang, Lâm Minh Đang and Marc Pilon (2010) Hot water treatment prevents Aphelenchoides besseyi damage to Polianthes tuberosa crops in the Mekong Delta of Vietnam. Crop Protection 29:599-602.
28. Mörck, C., Vivekanand V., Jafari, G. and Pilon, M. (2010). C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants. BMC Dev. Biol. 10:55.
29. Jafari, G., Burghoorn, J., Kawano, T., Mathew, M., Mörck, C., Axäng, C., Ailion, M., Thomas, J., Culotti, J., Swoboda, P. and Pilon, M. (2010) Genetics of Extracellular Matrix Remodelling During Organ Growth Using the C. elegans Pharynx Model. Genetics 186:969-982.
30. Svensson, E., Olsen, L., Mörck, C., Brackmann, C., Enejder, A., Faergeman, N. J. and Pilon, M. (2011). The adiponectin receptor homologs in C. elegans promote energy utilization and homeostasis. PLoS ONE 6(6):e21343
31. Rauthan, M., Ranji, P., Pradenas, N. A., Pitot, C. and Pilon, M. (2013). The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. PNAS 110:5981-5986.
32. Svensk, E., Ståhlman, M., Andersson, C.-H., Johansson, M., Borén, J. and Pilon, M. (2013). PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genetics 9:e1003801.
33. Ranji, P., Rauthan, M., Pitot, C. and Pilon, M. (2014). Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria. PLoS ONE 9:e100033.
34. Rauthan, M., Ranji, P., Abukar, R. and Pilon, M. (2015). A mutation in Caenorhabditis elegans NDUF-7 activates the mitochondrial stress response and prolongs lifespan via ROS and CED-4. G3: Genes, Genomes, Genetics. 5: 1639-1648.
35. Rauthan, M. and Pilon, M. (2015). A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans. WORM 4:e1096490.
36. Svensk, E., Devkota, R., Ståhlman, M., Ranji, P., Rauthan, M., Magnusson, F., Hammarsten, S., Johansson, M., Borén, J. and Pilon, M. (2016). Caenorhabditis elegans PAQR-2 and IGLR-2 protect against glucose toxicity by modulating membrane lipid composition. PLoS Genetics 12:e1005982.
37. Svensk, E., Biermann, J., Hammarsten, S., Magnusson, F. and Pilon, M. (2016). Leveraging the withered tail tip phenotype in C. elegans to identify proteins that influence membrane properties. WORM 5:e1206171.
38. Dahl-Halvarsson, M., Pokrzywa, M., Rauthan, M., Pilon, M. and Tajsharghi, H. (2017). Myosin storage myopathy in C. elegans and human cultured muscle cells. PLoS ONE 12:e0170613.
39. Devkota, R., Svensk, E., Ruiz, M., Ståhlman, M., Borén, J. and Pilon, M. (2017). The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids. PLoS Genetics 13:e1007004.
40. Devkota, R. and Pilon, M. (2018). FRAP: a powerful method to evaluate membrane fluidity in Caenorhabditis elegans. Bio-Protocols 8:e2913.
41. Bodhicharla, R., Devkota, R., Ruiz, M. and Pilon, M. (2018). Membrane fluidity is regulated cell nonautonomously by Caenorhabditis elegans PAQR-2 and its mammalian homolog AdipoR2. Genetics 210:189-201.
42. Ruiz, M., Bodhicharla, R., Svensk, E., Devkota, R., Busayavalasa, K., Palmgren, H., Ståhlman, M., Boren, J. and Pilon, M. (2018). Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2. eLife 7:e40686.
43. Ruiz, M., Ståhlman, M., Borén, J. and Pilon, M. (2019). AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin. J. Lipid Res. 60:995-1004.
44. Ruiz, M., Bodhicharla, R., Ståhlman, M., Svensk, E., Busayavalasa, K., Palmgren, H., Ruhanen, H., Boren, J. and Pilon, M. (2019). Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. eLife 8:e47733.
45. Zhang, X., Blockhuys, S., Devkota, R., Pilon, M. and Wittung-Stafshede, P. (2020). The Caernorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell migration. Biometals 33:147-157.
46. Busayavalasa, K., Ruiz, M., Devkota, R., Ståhlman, M., Bodhicharla, R., Svensk, E., Hermansson, N.-O., Boren, J. and Pilon, M. (2020). Leveraging a gain-of-function allele of Caernorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins. PLoS Genetics 16:e1008975.
47. Devkota, R., Henricsson, M., Borén, J. and Pilon, M. (2021). The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats. BBA Mol Cell Biol Lipids 1866:158883.
48. Ruiz, M., Palmgren, H., Henricsson, M., Devkota, R., Jaiswal, H., Maresca, M., Bohlooly-Y, M., Peng, X.-R., Boren, J. and Pilon, M. (2021). Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids. BBA Mol Cell Biol Lipids 1866:158884.
49. Devkota, R., Kaper, D., Bodhicharla, R., Henricsson, M., Borén, J. and Pilon, M. (2021). A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits. Genetics 219:iyab093.
50. Besse, L., Besse, A., Stolze, S. C., Sobh, A., Zaal, E. A., van der Ham, A. J., Ruiz, M., Phuyal, S., Büchler, L., Sathianathan, M., Florea, B. I., Borén, J., Ståhlman, M., Huber, J., Bolomsky, A., Ludwig, H., Hannich, J. T., Loguinov, A, Everts, B., Berkers, C. R, Pilon, M., Farhan, H., Vulpe, C. D., Overkleeft, H. S., and Driessen, C. (2021). Treatment with HIV-protease inhibitor Nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple myeloma. Cancer Res. 81:4581-4593.
51. Ruiz, M., Henricsson, M., Borén, J. and Pilon, M. (2021). Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2. Lipids Health Dis. 20:173.
52. Ruiz, M., Svensk, E., Einarsson, E., Podda, E. and Pilon, M. (2022). A small molecule screen for paqr-2 suppressors identifies Tyloxapol as a membrane fluidizer for C. elegans and mammalian cells. BBA_Biomembranes 1864:183959.
53. Petkevicius, K., Palmgren, H., Glover, M., Ahnmark, A., Andréasson, A.-C., Madeyski-Bengtson, K., Kawana, H., Allman, E., Kaper, D., Uhrbom, M., Andersson, L., Aasehaug, L., Forsström, J., Wallin, S., Ahlstedt, I., Leke, R., Karlsson, D., Pellegrini, G., Aoki, J., Sienski, G., Pilon, M., Bohlooly-Y, M., Maresca, M. and Peng, X.-R. (2022). TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis. Nat. Comm. 13:6020.
54. Ruiz, M., Devkota, R., Panagaki, D., Bergh, P.-O., Kaper, D., Henricsson, M., Nik, A., Petkevicius, K., Höög, J. L., Bohlooly-Y, Carlsson, P., Borén, J. and Pilon, M. (2022). Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis. Nat. Comm. 13:7162.
55. Ruiz, M., Panagaki, D., Höög, J. L. and Pilon, M. (2023). Striking membrane defects in AdipoR-deficient cells. J. Lipid Res. 64:100335.
56. Ruiz, M., Devkota, R., Kaper, D., Ruhanen, H., Busayavalasa, K., Radovic, U., Henricsson, M., Käkelä, R., Borén, J. and Pilon, M. (2023). AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity. J. Biol. Chem. 299:104799.
57. Laudette, M.,Lindbom, L., Arif, M., Cinato, M., Ruiz, M., 3, Stephen Doran, S., Miljanovic, A., Rutberg, M., Andersson, L., Klevstig, M., Henricsson, M., Bergh, P.-O., Bollano, E., Aung, N., Smith, J. G., Pilon, M., Hyötyläinen, T., Orešič, M., Perkins, R., Mardinoglu, A., Levin, M. C. and Borén, J. (2023). Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function. Cardiovasc. Res. 119:1537-1552.
58. Palmgren, H., Petkevicius, K., Bartesaghi, S., Ahnmark, A., Ruiz, M., Nilsson, R., Löfgren, L., Glover, M. S., Andréasson, A.-C., Andersson, L., Becquart, C., Kurczy, M., Kull, B., Wallin, S., Karlsson, D., Hess, S., Maresca, M., Bohlooly-y, M., Peng, X.-R. and Pilon, M. (2023). Elevated adipocyte membrane phospholipid saturation does not compromise insulin signaling. Diabetes 72:1350-1363.
59. Zhang, J., Ruiz, M., Bergh, P.-O, Henricsson, M., Stojanovic, N., Devkota, R., Henn, M., Bohlooly-Y, M., Hernández-Hernández, A., Alsheimer, M., Borén, J., Pilon, M.* and Shibuya, H*. (2024). Regulation of meiotic telomere dynamics through nuclear envelope fluidity governed by AdipoR2-ELOVL2. (2024) Nat. Comm. (in press).
Reviews:
1. Pilon, M. and Weisblat, D. A. (1997). Early Events in Cell Fate and Lineages in Leech Embryos. Semin. Cell and Dev. Biol. 8:351-358.
2. Pilon, M. and Mörck, C. (2005). Development of the Caenorhabditis elegans pharynx, with emphasis on its nervous system. Acta Pharmacol. Sin. 26:396-404.
3. Pilon, M. (2005). The amazing world of nematodes. Trends Parasitology 21:309-310.
4. Mörck, C. and Pilon, M. (2006). Caloric restriction and autophagy in C. elegans. Autophagy 3:51.
5. Pilon, M. (2008). Fishing lines, time-delayed guideposts and other tricks used by developing pharyngeal neurons in C. elegans. Dev. Dyn. 237:2073-2080.
6. Pilon, M. (2009). The C2H2 Protein Family in C. elegans. In “Focus on Zinc Finger Protein Research”, Kenishi Yoshida (Book Ed). Publisher: Research Signpost, Kerala, India. 2009.
7. Rauthan, M. and Pilon, M. (2011). The mevalonate pathway in C. elegans. Lipids Health Dis. 10:243.
8. Pilon, M. (2014). Developmental genetics of the Caenorhabditis elegans pharynx. WIREs Dev. Biol. 3:263-280.
9. Pilon, M. (2016). Revisiting the membrane-centric view of diabetes. Lipids Health Dis. 15:167.
10. de Mendoza, D. and Pilon, M. (2019). Control of membrane lipid homeostasis by lipid-bilayer associated sensors: a mechanism conserved from bacteria to humans. Prog. Lipid Res. 76:100996.
11. Pilon, M. (2021). Paradigm shift: the primary function of the “Adiponectin Receptors” is to regulate cell membrane composition. Lipids Health Dis. 20:43.
12. Pilon, M. and Ruiz, M. (2023). PAQR proteins and the evolution of a superpower: Eating all kinds of fats. BioEssays 45:e2300079.
PhD Thesis:
Peng-Pilon, M. (1994) Title: The latent membrane protein 1 of Epstein-Barr virus: transient expression and phenotypic effects in human B cells.